Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition.

In the epileptic brain, seizure activity induces expression of the blood-brain barrier efflux transporter, P-glycoprotein, thereby limiting brain penetration and therapeutic efficacy of antiepileptic drugs. We recently provided the first evidence that seizures drive P-glycoprotein induction through a pathway that involves glutamate-signaling through the NMDA receptor and cyclooxygenase-2 (COX-2...

Developing a CoMSIA model for inhibition of COX-2 by resveratrol derivatives

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

Prostacyclin Synthesis by COX-2 Endothelial Cells: Selective Up-Regulation of in Prostanoid Production by Human Roles of Cyclooxygenase (COX)-1 and COX-2

Effect of intracerebroventricular injection of COX-1 inhibitor (ketoprofen) on PTZ-induced seizures in male rat

Introduction: Ketoprofen is an NSAID and selective COX-1 inhibitor. In our previous study the role of flunixin meglumine, a nonselective COX inhibitor was studied on seizure and its anticonvulsant effects were confirmed. Therefore this research is performed to assess the role of a selective COX-1 inhibitor, ketoprofen in treatment of seizures induced by PTZ. Methods: In this research, male ...

Developing a CoMSIA model for inhibition of COX-2 by resveratrol derivatives

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...